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There is considerable complexity underlying the mechanisms through which the TGF-β signaling pathway regulates the initiation and progression of cancer. Analysis of this pathway and the role that it plays in human malignancy continues to elucidate novel mechanisms through which various genetic and epigen...
AIM: To study the pathophysiological mechanism of cardiomyopathy, the expression of TGF-βand apoptosis in myocardium of diabetic rats were investigated. METHODS:The diabetes models were established by single intravenous injection of streptozotocin (50 mg/kg) in rats. By the method of immunochemistry,...
Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called "pan-specific" antibody molecules, and uses of such antibody molecules. Preferred embodiments within ...
TGF-β promotes rotator cuff muscle fibrosis and fatty infiltration by preventing FAP apoptosis. TGF-β regulated FAP apoptosis may serve as an important target pathway in the future development of novel therapeutics to improve muscle outcomes following rotator cuff tear. 展开 ...
Thus, TGF-#946;1 not only negatively controls the growth of PDL-derived EPC-like fibroblastic cells via a Smad-dependent manner but also positively controls the SMC-differentiation of the cells possibly at the early stage of the translineage commitment via Smad- and p38 MAPK-dependent manners....
The aim of our current study was to elucidate the effects of dual inhibition of PDGF and TGF-beta by combination of the clinically used imatinib mesylate (STI-571) and perindopril (an ACE-inhibitor; ACE-I), respectively, on ongoing liver fibrosis development in rats. The effects of STI-571...
TGF信号传导通路通过调节下游基因的表达,促进细胞增殖和分化。 细胞凋亡:TGF也能够诱导某些细胞的凋亡,如黑色素瘤细胞等。这种凋亡作用是通过激活Smad3和抑制抗凋亡蛋白Bcl-2实现的。 免疫调节:TGF能够抑制免疫细胞的活化和增殖,具有免疫抑制作用。在某些自身免疫性疾病和移植排斥反应中,TGF的表达水平会升高,发挥免疫...
最后,除了经典的Smad通路,TGF-β家族细胞因子也能以细胞类型依赖的方式激活一些其他信号分子。 TGF-β细胞信号转导通路在不同的层面受到精细的调控,包括配体、受体、Smad以及核内转录水平的调控;其调控机制多种多样,比如蛋白-蛋白相互作用...
在医学研究中,信号通路一直是重中之重。信号通路像是桥梁,将生物分子和临床疾病联系在了一起,使临床表型和基础研究相结合。 在不同的文章中,虽然研究的是不同的分子,但是却有可能具有相似的研究框架,甚至是相同的疾病模型。 所以,在...