Previous evidence about the effects of lowering cholesterol in people with diabetes has been limited, and most diabetic patients do not currently receive cholesterol-lowering therapy despite their increased risk. Methods: 5963 UK adults (aged 40-80 years) known to have diabetes, and an additional ...
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References (1) Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial Lancet (2002)Cited by (5) Antioxidant supplements for prevention of mortality in healthy participants...
Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360: 7-22. PMID: 12114036MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in ...
Summary Background Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with lower cardiovascular disease risk. In such populations, therefore, reducing LDL cholesterol may reduce the development of vascular disease, largely irrespective of initial ...
MRC/BHF Heart Protection Study Collaborative Group 1999 MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experiences. Eur Heart J 20:725-...
Interpretation: Adding simvastatin to existing treatments safely produces substantial additional benefits for a wide range of high-risk patients, irrespective of their initial cholesterol concentrations. Allocation to 40 mg simvastatin daily reduced the rates of myocardial infarction, of stroke, and of re...
Articles MRC / BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes : a randomised placebo- controlled trialProtection, HeartCollaborative, Study
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.doi:10.1016/S1062-1458(02)00911-XingentaconnectACC Current Journal Review
Need for large scale randomized evidence about lowering LDL cholesterol in people with diabetes mellitns:MRC/BHF heart protection study and other major trials[J].Heart,2000,(04):357-360.doi:10.1136/heart.84.4.357.Armitage J, Collins R: Need for large scale randomised evidence about lowering ...