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These data provide insights into how BMP-2 and BMP-4 may model and control the growth of skeletal elements during normal embryonic development, suggesting roles for both molecules in recruiting non-chondrogenic precursors to chondrogenic fate. 展开 关键词: Animals Extremities Cartilage Bone and ...
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Adenovirus vectors containing constitutively active HA-tagged Alk3 Q233D (Ad-BMPRIA-QD) and Alk6 Q203D (Ad-BMPRIB-QD) were kindly provided by Anita Roberts, National Cancer Institute, MD. Cell Culture and Adenovirus Infection 2T3 cells were isolated and cloned from a transgenic mouse with ...
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Here, the rescue was efficiently achieved with both caSmad1 and caBMPR, suggesting that the mechanisms controlling wnt8 expression after Fhl3 KD were more direct than those controlling snai2 (Figures 2C and 3D). This also suggested that in both assays Fhl3 might enhance Smad1 activity, ...
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-silenced (Sh-Pdia3) and VDR-silenced (Sh-VDR) pre-osteoblastic MC3T3-E1 cells with either 1,25(OH)2D3, or BMP2, or with 1,25(OH)2D3 and BMP2 together, and measured osteoblast marker expression in 2D culture and mineralization in a 3D poly(ε-caprolactone)–collagen scaffold model....
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3DD196is a hypomorphic allele harboring a stop codon following the α2peptide; andα2δ-3k10814(here calledα2δ-3k) is a hypomorphic P element allele with reduced expression of wild-type protein17,18(Fig.7e). While bouton formation is blocked inα2δ-3DD106homozygotes,α2δ-3DD196...