Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle. In addition to their well-...
Cell cycle control in multicellular eukaryotes has an additional layer of complexity, as multiple CDKs and cyclins are required. In this review, we will discuss recent advances in the area of cyclins and CDKs, with emphasis on the role of the mammalian proteins in cell cycle control at the ...
and intimal proliferation were equal to advertitia;VSMC in intimal and advertitia were all expressed cdk's/cyclins.In A and B groups,vasa vasorum early expressed α actin,PCNA,cdk's and cyclins.Following inflammatory infiltration accelerately,they expressed more early and obviously.If vasa vasorum...
Molecular and biochemical studies have defined the complex interactions between the cyclins, CDKs and the CKIs. Mitogen-stimulated progression through the G1 phase of the cell cycle and initiation of DNA replication in S phase are coordinated by the CDKs, the activities of which are regulated by...
(1997). The Josef Steiner Lecture: CDKs and cell-cycle ... P Nurse - 《International Journal of Cancer》 被引量: 41发表: 2015年 Cyclins, Cyclin-Dependent Kinases and Cdk Inhibitors: Implications in Cell Cycle Control and Cancer A significant portion of cell scientific literature published is...
Cyclin-dependent kinases (CDKs) expression was downregulated by overexpressing PLCD1 in vitro and in vivo. (a) Western blotting of CDKs and cyclins in KD-PLCD1 cell line in vitro. (b) Western blotting of CDKs and cyclins in OE-PLCD1 cell line in vitro. (c) Antitumor effect of PLCD1...
Remarkably, compared to animals, plants have many more members in the CDK and cyclin families. Some of these members are unique and can only be found in plants [18]. This evolution in the number of plant CDKs and cyclins means that different complexes can phosphorylate a wide range of ...
Expression of cyclins A and E and cyclin-dependent kinase 2 (CDK2) was examined immunohistochemically in 190 cases of human lung carcinoma. Cyclin A and CDK2 were expressed in the majority of squamous cell carcinomas, small cell carcinomas, and large cell carcinomas, but in significantly ...
网络周期素依赖激酶 网络释义 1. 周期素依赖激酶 既与肿瘤抑制作用密切相关,又能通过抑制周期素依赖激酶(Cyclin-dependent kinases CDKs)复合物活性,协调细胞周期、D… baike.baidu.com|基于 1 个网页 例句
CDKs与癌症关系的研究进展 在过去的20年中,大量文献表明人类的癌症与细胞周期异常有关。肿瘤细胞形成的突变是导致特定的促有丝分裂信号系统和对抗有丝分裂信号系统 的缺陷反应,这有助于异常增殖[1,2]。大多数肿瘤需要基因的不稳定性导致肿瘤细胞形成的突变及染色 体的不稳定,从而使染色体的数目改变[3,4...