In this issue of Blood, Jacobsohn et al report that 2 simple and reproducible assess-ment tools, the National Institutes of Health (NIH) composite skin score and the Lee skin symptom scale, are powerful predictors of severity and prognosis of skin GVHD....
Additional findings from the study showed that among patients treated at the 0.3 mg/kg dose, 55% experienced a clinically meaningful improvement in symptoms, as measured by at least a seven-point decrease in the modified Lee chronic GVHD Symptom Scale score. ...
Approval was granted based on results from the ROCKstar study (NCT03640481) during which the ORR was assessed as the primary end point, and the key secondary end points evaluated were duration of response, change in Lee Symptom Scale Score, OS, FFS, and change in GVHD severity. ROCKstar sh...
” Wolff noted. Moreover, 73% of patients experienced improved mLSS skin thickened score vs baseline, “underlying the crucial importance of capturing patient-reported
Correlation between NIH composite skin score, patient reported skin score and outcome: results from the chronic GVHD Consortium. Blood 2012; 120: 2545–2552. Article CAS Google Scholar Greinix HT, Loddenkemper C, Pavletic SZ, Holler E, Socie G, Lawitschka A et al. Diagnosis and staging...
In a model adjusted for gender, age, time since transplant, donor type and conditioning regimen, subjects with cGVHD were more likely to report adverse general health, functional impairments, activity limitation, pain and to score in the lowest 10% of population norms on the BSI compared to ...
Additional endpoints include Duration of Response (DOR), corticosteroid (CS) dose reductions, Failure Free Survival (FFS) and Lee Symptom Scale (LSS) score. Results 17, 16, and 21 pts enrolled in C1, C2, and C3. As of 8Mar19, median duration of follow up was 112, 97 and 64 weeks ...
S1624 A DAY 100 LAB-SCORE PREDICTS EXTENSIVE CGVHD, OVERALL SURVIVAL AND TRANSPLANT-RELATED MORTALITY AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: FINAL ANALYSISdoi:10.1097/01.HS9.0000564744.69369.fcMetafuni, E.Cavattoni, I.Lamparellli, T.
“Eighty-seven percent of patients experienced improvement compared with baseline,” Wolff noted. Moreover, 73% of patients experienced improved mLSS skin thickened score vs baseline, “underlying the crucial importance of capturing patient-reported outcomes in this patient population,” he said. “...
cGVHD of skin: simple tools, great advances.In this issue of Blood, Jacobsohn et al report that 2 simple and reproducible assessment tools, the National Institutes of Health (NIH) composite skin score and the Lee skin symptom scale, are powerful predictors of severity and prognosis of skin ...