8 Attempts to isolate the pathologic agent from symptomatic individuals during the outbreak also diverged from previous experience with dengue virus (DENV): Inoculation of infant mice with serum samples from symptomatic individuals resulted in death of the animals. In contrast, DENV infection is ...
Summary Chikungunya is a re-emerging viral infection. Persisting arthralgia is the major symptom of this infection. Transmission cycles of Chikungunya virus (CHIKV) can be man-mosquito-man (urban cycle) or animal-mosquito-man (sylvatic cycle). Monkeys, rodents, and birds have been reported to ...
After acute chikungunya infection, striking hyperpigmentation of the skin may occur, including postinflammatory hyperpigmentation, freckling, streaks, and broad areas of hyperpigmentation. A bullous eruption may occur in acute chikungunya virus infection. About 90% of those with a bullous eruption are ...
Geographical mapping of incidence rates of Chikungunya virus infection in Indonesian provinces from 2008 to 2016 (per 100,000 persons). Annual number of chikungunya cases from each Indonesian province was extracted from the Ministry of Health of the Republic Indonesia and the map was created using A...
and polyarthralgia are also commonly observed in infected individuals, with debilitating polyarthralgia displaying positive predictive value of chikv infection in endemic and epidemic areas. a maculopapular rash, similar to that observed during dengue virus infection, may also develop and last for upw...
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere. Current reports evidenced that after outbreaks in 2005–06, the fitness of this virus propa
Here we identified the four-and-a-half LIM domain protein 1 (FHL1)3 as a host factor that is required for CHIKV permissiveness and pathogenesis in humans and mice. Ablation of FHL1 expression results in the inhibition of infection by several CHIKV strains and o’nyong-nyong virus, but ...
Most studies have been focused on understanding the pathogenesis of CHIKV infection through clinical observation and with animal models. In this review, the clinical manifestations of CHIKV that define the disease and the use of relevant animal models, from mice to nonhuman primates, are discussed....
“alphavirus infection”. VOSviewer also assigned colors to chikungunya-related terms based on publication years (Fig.3b). Purple indicates that the terms appear in the early years, whereas the yellow color is designated for terms that emerge in recent years. The progress of research on ...
Chikungunya virus (CHIKV) is an emerging arbovirus of the Togaviridae family that poses a present worldwide threat to human in the absence of any licensed vaccine or antiviral treatment to control viral infection. Here, we show that compounds interfering