The chapter presents an investigation concerning the C-terminal sequence by the technique of hydrogen-tritium replacement has been recently initiated.doi:10.1016/B978-0-12-211850-0.50006-9P. DesnuelleD. GratecosM. CharlesR. PeanaskyM. RoveryStructure–Function Relationships of Proteolytic Enzymes...
Mechanisms and development of pancreas and pancreatic secretory function were studied in the rat. Injections of cholecystokinin octapeptide and hydrocortis... SL Werlin,J Stefaniak - 《Neonatology》 被引量: 28发表: 1983年 Differential Response of Embryonic Chick Pancreas Enzymes to Glucocorticoids - Sc...
The spectral positions of the decay‐associated spectra of the hydrated powders do not shift as a function of hydration. This indicates that the structures of the zymogen and the active enzyme are unaffected by hydration. The lifetimes of α‐chymotrypsinogen A in phosphate buffer pH 7.4 are τ...
Although this is a dominant theme, there is clearly heterogeneity, which we believe is a function of both the severity and/or repetition of the injury and the individual's immune response to (recurrent) pancreatic injury. Thus, in the North American Pancreatitis Study I...
The observed rate coefficient (kobs) for aggregation displays a maximum as a function of temperature because of the competition between folding−unfolding thermodynamics and the intrinsic growth and nucleation rates; the latter contribution has a large, negative activation enthalpy that dominates kobs ...
作者: EL Smith,DM Brown,M Laskowski 展开 摘要: PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. 展开 关键词: CHYMO...
The Carboxylic functions play an important structural role in trypsinogen, chymotrypsinogens A and B, trypsin, and chymotrypsin.doi:10.1016/B978-0-12-211850-0.50008-2M. LAZDUNSKIM. DELAAGEJ.P. ABITAJ.P. VINCENTStructure–Function Relationships of Proteolytic Enzymes...
At all denaturant concentrations the enthalpy term slightly dominates the entropy term in the Gibbs free energy function. The most obvious effect of alkylureas was lowering of the temperature of transition, which was increasing with alkylurea concentration and the size of alkyl chain. Destabilization...
PlanckBenzinger Thermal Work Function: Determination of the Thermodynamic Stability of Chymotrypsinogen A and Ribonuclease A in Glycerol A method is described for evaluating the temperature-invariant enthalpy, ΔH°(T0), for chymotrypsinogen A and ribonuclease A in an aqueous glycerol soluti... Chun,...
Three important protons to the function of the triad are Ser195-Hgamma, His57-Hepsilon2, and His57-Hdelta1. NMR spectroscopic methods have been hindered in observing His57-Hepsilon2 owing to fast exchange and line-broadening, and Ser195-Hgamma has never been detected. The His57-Hepsilon...