Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Prion disease Caused by Gene mutations Abnormal post-translational modifications Infection of prion protein in the brain Cleaved to generate N-terminal polyQ fragments Aggregates form in cytoplasm and in nucleus-amyloid-like conformation ...
KEY WORDS: Pertussis, Pediatric infectious disease, Vaccines *** Pertussis is a serious respiratory infection that was first described in the 1500s. The original description of the clinical syndrome of pertussis is credited to Guillaume de Baillou during an ...
part of Phase 3 (15%), or enter Phase 2 again (35%) or, under our experimental conditions, enter Phase 1 again (50%). We consider an animal behaving in Phase 1 as least constrained, meaning that all behavioral options are open depending on the internal state and the external stimuli, ...
(CNS). One characteristic feature of cytokines is their functional redundancy and pleiotropism; a wide variety of cell types respond to cytokines, thereby regulating systemic homeostatic functions including host responses to infection, immune system signaling, inflammation, and trauma. This chapter ...
before rituximab infusion and development of serious infection events. thus, in contrast to igg, low baseline igm at treatment initiation or subsequent development of hypo-igm do not appear to be associated with elevated risks of infection in ra patients. concerning neurological diseases, a recent ...
(hemisphere) of the brain. Aphasia usually occurs suddenly, often as the result of a stroke or head injury, but it may also develop slowly, as in the case of a brain tumor, an infection, or dementia. The disorder impairs the expression and understanding of language as well as reading ...
However, after correction of Kp,brain for brain tissue uptake (using Vu,brain derived from the brain slice method) and plasma protein binding (using fu,plasma) the BBB net flux was estimated as a 0.14 meaning that only 14% of unbound drug in plasma is passing the BBB. Moreover, after ...
When symptoms are present, urinary tract infection and a large post void residual urine should be excluded. Patients can be asked to fill out a bladder diary for several days to provide information about how often they urinate, the volume of urine produced, and any episodes of incontinence. ...
[13,14]. In general, in cells that express EAT-2, SLAMF7 signaling is activating and in the absence of EAT-2, it is inhibitory [13,15]. We have previously defined roles for SLAMF7 in a number of conditions including HIV infection [15] and cancer [16], and have also worked to ...
Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms. J Virol. Feb. 2006;80(3):1340-51. Colman, P.M. Effects of amino acid sequence changes on antibody-antigen interactions. Res Immunol. Jan. 1994...