Brent Stockwell博士在2012年领导了一组研究人员发现了铁死亡。 哥伦比亚大学生物科学系、化学系和哥伦比亚大学欧文医学中心的教授在《Cell》杂志上发表了题为“Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis”的研究。 “含有单一多不饱和脂肪酸酰基尾部的磷脂(PL-PUFA1)被认为是铁死亡的驱动...
这项研究《Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis》发表在《Cell》上,由哥伦比亚大学生物科学系、化学系和哥伦比亚大学伊灵医学中心的教授进行。 研究人员写道:“含有单个多不饱和脂肪酰尾(PL-PUFA1s)的磷脂被认为是促进铁死亡的主要驱动力,而具有双酰基-PUFA尾(PL-PUFA2s)的磷脂...
The fatty acid composition of phospholipids of spermatozoa from infertile patients. Mol Hum Reprod 1998; 4: 111-8.Zalata AA , Christophe AB , Depuydt CE , Schoonjans F. , Comhaire FH . The fatty acid composition of phospholipids of spermatozoa from infertile patients . Mol Hum Reprod . ...
17-Hydroxyoctadecanoic acid17-Hydroxystearic acid17-OH-18:0 The main positions of attachment of the hydroxyl to the chain are theα-attachment to the C2site, and theβ-attachment to the C3site. The general formula forα-hydroxy fatty acids is CH3(CH2)nCH(OH)COOH, while theβ-hydroxy fatt...
Intestinal barrier function is commonly described as the capacity of the GI epithelium to prevent the penetration by luminal bacteria and dietary allergens into the mucosa [1]. Several components form the multi-layered intestinal barrier. In the lumen, gastric acid and pancreatic juice degrade ...
What is a fatty acid called in which all carbon atoms are bonded via single bonds to other carbon and hydrogen atoms? What is a Fatty Acid? Fatty acids are a type of lipid containing a carboxylic acid attached to a long aliphatic chain. Most ...
composed of a glycerol central moiety conjugated to two fatty acid esters (“tail group”) and inositol ring (“head group”)14. The “head group” status of these lipids play a key role in biology of PIPs, whereas the lipid tails play a limited role in signaling14. Therefore, the expre...
Structured PLs (SPLs) are PLs that can be formed with specific fatty acyl groups in thesn-1 and/or 2 position(s) of PLs through enzymatic acidolysis catalyzed by PLA1, PLA2, and various lipases from bacteria and fungi. As can be seen in recent studies (Table 7.4), incorporation of sp...
and changes in the process’s activity have an impact on the type and extent of obesity. the phospholipids in the cell membrane play a crucial role in maintaining the fluidity of the membrane. it is thought that a diet with a high polyunsaturated fatty acid to the saturated fatty acid ratio...
The brain is especially enriched with the two polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid. Although, quantitatively speaking, they are primarily esterified to brain phophospholipids, they can be released from the membrane and transformed into highly biologically active molecules. Th...