Information on FGF genes activated to determine the role of the FGF; Genes that display AER specific expression domains; Analysis of genes Fgf4 and Fgf8 function.SunXinMarianiFrancescaV.MartinGailR.EBSCO_AspNatureSun X, Mariani FV, Martin GR. Functions of FGF signalling from the apical ...
Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak Development, 124 (Jul 1997), pp. 2829-2841 CrossrefView in Scopus 39 X. Sun, E.N. Meyers, M. Lewandoski, G.R. Martin Targeted disruption of...
Summary The fibroblast growth factor (FGF) family consists of 22 ligands in mice and humans. FGF signaling is vital for embryogenesis and, when dysregulated, can cause disease. Loss-of-function genetic analysis in the mouse has been crucial for understanding FGF function. Such analysis has reveale...
Basic fibroblast growth factor (FGFbasic), also known as bFGF, FGF2, FGF-β, or HBGF-2, belongs to the FGF family. FGF plays important roles in diverse biological functionsin vivoandin vitro. FGF is involved in embryonic development, neuron differentiation, and the proliferation of cells of...
3.1.4FGF9 (fibroblast growth factor) FGF9has an important function in testicular development. It has many roles such as cell proliferation, cell survival, cell migration and differentiation [57]. When newly differentiated Sertoli cells begin to produce FGF9, it may maximally reach the level at ...
(Fgf2−/−) mice have normal limbs. The normal skeleton inFgf2−/−mice indicates that the function of FGF2 may be replaced by FGF8 and FGF4,99which is also expressed in the limb bud. FGF2 also plays important roles in bone homeostasis. Deletion ofFgf2in mice leads to decreased...
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thefunctionofFgfinzebrafishliverisnotyetwellunderstood,specificallyforpostnatalhomeostasis.Thecurrentstudyanalyzedtheexpressionoffgfreceptors(fgfrs)intheliverofzebrafish.WetheninvestigatedthefunctionofFgfsignalinginthezebrafishliverbyexpressingadominant-negativeFgfreceptorinhepatocytes(lfabp:dnfgfr1-egfp,lf:...
but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively sp...
4. Loedige, I., Gaidatzis, D., Sack, R., Meister, G. & Filipowicz, W. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.Nucleic Acids Res. 41, 518–532 (2013).