参考资料:标题:Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions作者:Rafiou Agoro, Kenneth E. White期刊:Nature Reviews NephrologyDOI: 10.1038/s41581-022-00665-xPDF 下载链接:https://is.gd/sLRYzB — 完 —关注我,记得标星哦~
参考文献: Fukumoto S . FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment[J]. Journal of Molecular Endocrinology. 2020, 66(2). 版 权 声 明 版权属罕见病新进展所有,欢迎个人转发分享,其他任何媒体、网站如需...
接着,作者检测了肾静脉内所有分子与动脉内全长FGF23(intact FGF23, iFGF23)水平的关联性(图1D),其中只有代谢物3-磷酸甘油(glycerol-3-phosphate, G-3-P)具有显著统计学意义(r2= 0.76,P= 5.2 × 10–6)。 G-3-P是一种极性小分子,会被肾小...
H Juppner,M Wolf,IB Salusky.FGF-23: more than a regulator of renal phosphate handling?. Journal of Bone and Mineral Research . 2010H. Ju¨ppner, M. Wolf, and I. B. Salusky, "FGF-23: more than a regulator of renal phosphate handling?" Journal of Bone and Mineral Research, vol. ...
肾性磷酸盐消耗综合征(Renal phosphate wasting syndromes)由一组异质性疾病组成,具有多种病因,在生化上表现为低磷酸盐血症。低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。
基因:由磷酸盐调节内肽酶同源物X连锁(phosphate-regulating endopeptidasehomolog X-linked,PHEX)基因突变引起; 机制:PHEX基因在骨细胞中表达,其失活导致FGF-23浓度升高,机制尚不清楚; 通常出现在儿童时期,但较轻症疾病可能直到成年后才被发现; 这种类型的低磷血症与更常见的维生素D缺乏相比,碱性磷酸酶的升高相对较小...
FGF23 is a bone-derived growth factor that can influence the homeostasis of phosphate and vitamin D Systemic regulation of phosphate homeostasis by FGF23 is dependent on the activity of the membrane protein Klotho Determination of serum FGF23 levels might improve the diagnosis and prognosis of vario...
原文出处:FDAapproves First Therapy for Rare Disease that Causes Low Phosphate Blood Levels, Bone Softening 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“...
在这些疾病中,由X-连锁调节磷酸盐的内肽酶同源物(Phosphate-regulating Endopeptidase Homolog X-linked, PHEX)基因的失活性突变引起的X-连锁低磷酸盐血症(X-linked Hypophosphatemia, XLH)是引起遗传性FGF23相关的低磷酸盐血症性佝偻病的最常见形式。另一种与FGF23相关的低磷酸盐血症是肿瘤诱导的骨软化症(Tumor-...
FGF23 is a hormone involved in the regulation of phosphate metabolism and vitamin D metabolism. Klotho protein is a transmembrane protein that can regulate the activity of FGF23. Studies have shown that FGF23 and Klotho proteins are related to cardiovascular disease. However, the relationship ...