Choi, M. G., Lee, J.-H., Sohn, T. S., Bae, J. M., Kim, S., Jung, S.-H., Kang, W. K., & Kim, K.-M. (2016). FGFR2 in gastric cancer: protein overexpression predicts gene amplification and high H-index predicts poor survival. Modern Pathology, 29(9), 1095–1103.[...
原文出处:Phase 2 FIGHT Trial Results Presented at ASCO GI Validate Importance of FGFR2b Overexpression and Reinforce Potential of Bemarituzumab Plus Chemotherapy as a Frontline Targeted Treatment for FGFR2b+ Gastric and GEJ Cancers 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片...
原文出处:Phase 2 FIGHT Trial Results Presented at ASCO GI Validate Importance of FGFR2b Overexpression and Reinforce Potential of Bemarituzumab Plus Chemotherapy as a Frontline Targeted Treatment for FGFR2b+ Gastric and GEJ Cancers
FGFR2靶向药物根据作用机制可分为四类:(1)小分子酪氨酸激酶抑制剂(TKIs),包括非选择性和选择性的FGFR抑制剂;(2)对抗性单克隆抗体,竞争性结合到FGFR细胞外区域,阻止FGFs–FGFR信号的激活;(3)FGF配体陷阱,阻止多种FGF配体的活性和配体-受体相互作用;以及(4)抗体-药物结合物(ADCs),由FGFR抗体与细胞毒性荷载组成。
KGFR depletion by small interfering RNA microinjection and overexpression by transfection of wild type or defective mutant KGFR were performed to demonstrate the direct effect of the receptor on phagocytosis and melanosome transfer. Colocalization of the phagocytosed beads with the internalized ...
had received no prior therapy for histologically confirmed advanced or meta- static G/GEJC, not known to be HER2-positive, had evalu- able disease (RECIST version 1.1), had Eastern Coopera- tive Oncology Group (ECOG) performance status 0 or 1, and FGFR2b overexpression by IHC and/or FGF...
Overexpression of miR-125b in primary human keratinocytes suppressed proliferation and induced the expression of several known differentiation markers. Conversely, inhibition of endogenous miR-125b promoted cell proliferation and delayed differentiation. Fibroblast growth factor receptor 2 (FGFR2) was ...