简称:FVB-MMTV-PyMT 品系类型:转基因 品系编号:T004993 背景:FVB/NJGpt 品系描述 小鼠乳腺肿瘤病毒(Mouse mammary tumor virus:MMTV)是导致小鼠乳腺肿瘤的重要病毒,利用其病毒组织特异启动子及增强子功能,可介导癌基因ERBB2、PyMT、wnt-1在小鼠乳腺高表达而发生乳腺癌[1]。我们使用MMTV-LTR(long terminal repeat :...
Female mice transgenic for the rat proto-oncogene c-erb-B2, under control of the mouse mammary tumor virus (MMTV) promoter (neuN), spontaneously develop metastatic mammary carcinomas. The development of these mammary tumors is associated with increased number of GR-1 + CD11b + myeloid derived ...
Reduced tumor latency in adiponectin haplodeficient MMTV-PyVT mice of both FVB/N and C57BL/6J genetic backgrounds.Janice B. B. LamKim H. M. ChowAimin XuKaren S. L. LamJing LiuNaiSum WongRandall T. MoonPeter R. ShepherdGarth J. S. Cooper...
These FVB/N derived mice express rat neu cDNA under the mammary-specific MMTV promoter, and develop spontaneous neu -expressing mammary tumors that are difficult to eradicate with neu -targeted vaccines. We have previously shown that these mice exhibit evidence of immune tolerance to neu -...