移植物抗宿主病(graft versus host disease, GVHD)是指用含有免疫活性细胞的组织(骨髓、胸腺等)植入有免疫缺陷的受者时, 移植物不遭排斥但对宿主细胞产生免疫损伤所致的疾病。GVHD是HSCT的主要并发症之一,同种异体HSCT后25%~70%患者可发生GVHD。 GVHD分类 急性(acute graft-...
The diagnostic criteria for ocular GVHD are based on parameters including ocular surface disease index, corneal fluorescein staining, and conjunctival injection; treatment is based on the severity of the disease, Jhanji noted. Preservative-...
GvHD可分为急性移植物抗宿主病(acute graft versus host disease,aGvHD)和慢性移植物抗宿主病(chronic graft versus host disease,cGvHD)。急性和慢性GvHD最初是根据其发生的时间来定义的,分别是在移植后100天之前或之后,但现在是根据病理学的差异来定义的,并被认为是在原来的时间范围之外发生的,在一些患者中是重叠...
Graft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantation.[J]. Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology, 2013, 31(12):1530-1538. 移植物抗宿主病是来自供者的造血干细胞在患者体内植活后,对患者的身体...
GVHD is a systemic inflammatory disease that affects 40% to 60% of allogeneic hematopoietic cell transplantation (allo-HCT) patients and accounts for 15% of deathsafter allo-HCT. GVHD can be divided into acute and chronic types. Acute GVHD(aGVHD)is an acute alloimmune inflammatory response chara...
人源PBMC(Peripheral Blood Mononuclear Cells)异体移植后的移植物抗宿主病(Graft-versus-Host Disease,GvHD)是一种严重的并发症,造成了PBM C移植后的小鼠出现严重的GvHD疾病并影响药效观测。因此,开发合适的模型来研究GvHD的发病机制、探索新的治疗策略以及评估抗体药物的疗效和安全性显得尤为重要。
移植物抗宿主病(graft—versus-host disease,GVHD):在骨髓移植时,用作移植的骨髓中常常混含供者T淋巴细胞,这些细胞与受者同种异型抗原发生应答,引起皮肤、肝、肠道等上皮细胞坏死,严重可致死亡。结果一 题目 植物抗宿主病〔graft-versus-host disease,GVHD〕 答案 移植物抗宿主病〔graft-versus-host disease,GVHD...
Barnes and Loutit first described (in mice) what is now known as graft versus host disease (GVHD) as a syndrome called secondary disease to differentiate it from primary disease of radiation sickness. Mice that were given allogeneic spleen cells after ir
Chronic GVHD as an autoimmune disease. Best Pract Res Clin Haematol. 2008;21(2):281-289.Tyndall A, Dazzi F. Chronic GVHD as an autoim- mune disease. Best Pract Res Clin Haematol. 2008;21(2):281-289.Tyndall A, Dazzi F. Chronic GVHD as an autoimmune disease . Best Pract Res Clin ...