Nobody knows exactly where the idea for making Jenkem came from, but it has been used by street-children in Lusaka for at least two years. Nason Banda of the Drug Enforcement Agency is not proud when he says that it is unique to Zambia. He shudders when he sees the boys at the sewa...
Definitions include: the psychedelic drugLSD(Lysergic acid diethylamide). shroom Definitions include: To ingest psychedelic mushrooms. electric Koolaid Definitions include: LSD ("acid") + Kool-Aid. mushrooms Definitions include: specifically, mushrooms containing psychedelic compounds. ...
JenKem Technology now offers large scale GMP manufacture of premium fatty acid side chain products for drug modification, with batch size as high as 10Kg-100Kg, with purity 90% or higher, and good lot-to-lot reproducibility. Fatty acid side chains are known to aid in improving patient co...
Keywords: Lipogenesis; Brain metastases; Blood‒tumor barrier; Wnt signaling; Drug delivery; Fatty acid synthase; Nanoparticles; Combination therapy; α-malemidyl-u-N-hydroxysuccinimidyl polyethyleneglycol 3500; MAL-PEG-NHS Dash, B., et al., Chitosan-coated magnetic graphene oxide for targeted ...
a molecular conformation which is similar to but better than liposome is formed by chemically bonding of the drug with the amphiphilic substance to obtain an increase bioavailability of drug, reduced dosage, reduced side effects and prolonged duration of action by using the targeting towards tumors....
Kwon, J., et al., Excitation-dependent emissive FeSe nanoparticles induced by chiral interlayer expansion and their multi-color bio-imaging. Nano Today, 2022, 43, p.101424. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nano...
Bock N, et al., GelMA, Click-Chemistry Gelatin and Bioprinted Polyethylene Glycol-Based Hydrogels as 3D Ex Vivo Drug Testing Platforms for Patient-Derived Breast Cancer Organoids. Pharmaceutics. 2023; 15(1):261. Li, H., et al., Synthesis of thiol-terminated PEG-functionalized POSS cross-link...
Ziegler, C. E., et al., A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications, European Polymer Journal, 2021, V. 147. Chang, C.-Y., et al., Triple click chemistry for crosslinking, stiffening, and annealing of gelatin-...
Conjugation with homobifunctional PEGs ensures an increased drug load compared to pegylation with linear PEGs. JenKem Technology offers Thiol PEG Thiol with MW 3,500 Da (HS-PEG3500-SH) and MW 5,000 Da (HS-PEG5000-SH), in 1g and 5g packing sizes. Different MW of PEG (Thiol)2 may be...
Drug Molecule or Other Entity PEGylated with Y-NHS-40K References Calcium phosphate nanoparticles 7 Cp40 4 DNA aptamer (SOMAmer) 2 G-CSF 15 Gentamicin 14 IFN-α2a 16 IFN-α2b 17 LIF receptor antagonist (LA) 11 L-RNA (Spiegelmer) 5 L-RNA (Spiegelmer) 8 rhGH 18 TNF-α 9, 10 Click...