2.2 肺癌患者与健康对照外周血中KCNMA1甲基化水 平的四分位分析 以每个 CpG 位点甲基化水平最低的四分位 Q1 作 A KCNMA1 B 图1 KCNMA1基因的位点分布图和序列 Fig.1 Site map and sequence of KCNMA1 gene. A: Position of KCNMA1 amplified fragment (487 bp) and the 4 measurable CpG sites. B: ...
Gene ID: 3778 种属 Homo sapiens DNA序列编号: NM_001014797.3 DNA描述 Homo sapiens potassium calcium-activated channel subfamily M alpha 1 (KCNMA1), transcript variant 1, mRNA DNA大小: 11982 bp DNA编码区: atggcaaatggtggcggcggcggcggcggcagcagcggcggcggcggcggcggcggaggc agcagtcttagaatgagtagcaatatcc...
2007. KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene 26 : 2525–2534Bloch M, Ousingsawat J, Simon R, Schraml P, Gasser TC, Mihatsch MJ, Kunzelmann K, Bubendorf L. KCNMA1 gene amplification promotestumor cell proliferation in human prostate ...
Abstract:Objective To explore the association of KCNMA1gene methylation levels in peripheral blood with lung cancer.Methods The methylation levels of 4CpG sites in KCNMA1gene were quantitatively detected in 285patients with lung cancer,186age-and sex-matched patients with benign pulmonary nodules and ...
Based on the bioinformatic analysis, the cell phenotypes and mouse model experiments were constructed to detect effect of the target gene. Using the Kaplan–Meier survival curve, the clinical value of KCNMA1 was assessed in GC patients. Results The CpG site cg24113782 located at the promoter of...
BackgroundMaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and...
Target genes of the lncRNA were determined using Multi-Experiment Matrix (MEM), a dual-luciferase reporter gene assay, and KEGG enrichment analyses. The results showed that MBNL1-AS1 was overexpressed in skeletal muscle cells in mice, while KCNMA1, which was enriched in the cGMP-PKG signaling...
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modu...
15 Notably, the loss-of-function mutations in the Kcnma1 gene cause impaired mitochondria and subsequently damaged neurite outgrowth and cellular viability.16 Nevertheless, whether myogenesis in the context of DM could be affected by Kcnma1 remains to be elucidated. In this study, we investigated ...
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modu...