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Kuro-o M, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature, 390(6655), 45-51. Kurosu H, et al. (2005) Suppression of aging in mice by the hormone Klotho. Science, 309(5742), 1829-1833. ...
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an ...
Klotho gene is an important gene involved in calcium homeostasis, and polymorphisms of this gene may render the individual prone to renal stone formation. We evaluated G395A single nucleotide polymorphisms (SNPs) of Klotho gene at rs1207568 in renal stone patients of North India. This was a ...
关键词:KLOTHO基因,基因多态性,心率变异性重庆医科大学硕士研究生学位论文THERELATIoNSHIPBETWEENKLoTHoGENEPoLYMORPHISMANDHEARTRATEVARlABILITYINELDEIUjYHYPERTENSIoNPATIENTSABSTRACTObjective 君,已阅读到文档的结尾了呢~~ 立即下载相似精选,再来一篇 文文 分享于2015-02-05 21:13...
The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
4. Dubal, D. B. & Yokoyama, J. S. Longevity gene KLOTHO and Alzheimer disease: a better fate for individuals who carry APOE epsilon4.JAMA Neurol. 77, 798–800 (2020). 转载须知 【非原创文章】本文著作权归文章...