A method for treating or preventing diseases accompanying aging of animals characterized by containing a compound having a divalent cationic metal and/or phosphorus; feeds for therapeutic or preventive use; foods for preventive or therapeutic use; a method of regulating the expression of klotho protein...
Klotho is a vital aging suppressor protein that has emerged in recent years. The klotho encodes a transmembrane alpha klotho (α−klotho) protein that is abundant in the kidney and brain [1]. After shedding the amino-terminal extracellular domain [2], soluble α-klotho can be found in circ...
(OH)2D3 is not a strict prerequisite for vitamin D responsiveness; for example, human adipocytes lack CYP27B1 activity yet express the vitamin D receptor (VDR), with vitamin D response element (VDRE)-responsive genes suppressing the expression of uncoupling protein-2 and the induction of ...
Background: Klotho is widely recognized as a protein that combats aging and possesses antioxidative characteristics, which have been implicated in the pathophysiology of numerous diseases. There is emerging evidence suggesting that the consumption of die
This protein serves numerous vital biological functions, including regulating phosphorus metabolism, mitigating oxidative stress, reducing inflammation, and modulating energy metabolism. Moreover, it is intricately linked with the regulation of aging [4]. In humans, Klotho protein levels typically exhibit ...