Multivariate analysis of logistic regression showed that Klotho protein (OR = 0.719 [0.598–0.866], p<0.001), albumin (OR=0.790 [0.686–0.910] p<0.001), left ventricular diastolic dimension (OR =1.135 [1.054–1.222], p<0.001), and left atrium dimension (OR=1.058 [1.013–1.106] p=0.012) ...
Administration of Klotho protein during IRI significantly increased LV work (p=0.001) and recovery of heart mechanical function (p=0.0003). Then, Klotho regulated the production of iNOS protein (p=0.020), ADMA (p=0.007), eNOS mRNA (p=0.021) and eNOS protein (p=0.041) to the levels ...
Among them, ischemic heart disease, due to myocardial infarction (MI) remains the first cause of cardiovascular death. The anti-ageing protein Klotho is mainly expressed in membrane at renal level. However, Klotho also has a soluble form with different pleiotropic functions that are still ...
All patients were monthly evaluated the levels of P, Ca, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP); the levels of FGF 23, Klotho protein and sclerostin were assessed once in 3 months. The dose of both drugs was adjusted according to the serum iPTH level. The nature, ...