Impaired renal functionType 2 diabetesNF-KB pathwayGenetic associationThe NF-kappaB pathway might play a role in the pathogenesis of renal disease and type 2 diabetes (T2DM). Our aim was to determine whether common polymorphisms in NF-kappaB genes were associated with impaired renal function and ...
In subject area: Biochemistry, Genetics and Molecular Biology Featured on this page Chapters and Articles You might find these chapters and articles relevant to this topic. miRNA-223 at the crossroads of inflammation and cancer Jacob Jeffries, ... Qing Deng, in ...
As it turns out, most agents that induce NF-kB activation, including tumor necrosis factor a (TNFa), interleukin 1 (IL-1), bacterial *Correspondence: M Karin lipopolysaccharide (LPS), viral double stranded (ds) RNA and ionizing radiation, all achieve complex disruption via a common pathway ...
Such responses are mediated to a large degree through changes in gene expression. One transcription factor that serves as a key responder to changes in the environment is NF- B, an evolutionarily conserved signaling module that plays a critical role in many biological processes. Understanding how ...
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具体而言,推断NFkB细胞信号 传导途径的活性可以如公开的国际专利申请W02013/011479A2 (“Assessment of cellular signaling pathway activity using probabilistic modeling of target gene expression”)或如公开的国际专利申请W02014/1026868A2中(“Assessment of cellular signaling pathway activity using I inear ...
Treatment with methoxyeugenol was able to reduce intralobular inflammation, decrease TNF-α, iNOS, IL-6, and IL-8 gene expression, as well as NF-kB protein expression. Methoxyeugenol increases the expression of PPAR-ɣ, which is considered an important factor in the metabolism of lipids and...
down-regulation of NF-kB, the final actor of a complex pathway of signal transduction finely modulated by ubiquitination at several levels [94]. Interestingly, definition of crosstalk between NF-kB signalling pathway, ubiquitin-dependent proteolysis and the critical chr 21 gene DSCR1 is still ...
评论次数: 0 文档热度: 文档分类: 论文--期刊/会议论文 文档标签: HowNF-kBisactivatedtheroleofIkBkinase40IKK41 系统标签: ikbkinaseactivatedikbsikbadidonato HowNF-kBisactivated:theroleoftheIkBkinase(IKK)complexMichaelKarin*,11LaboratoryofGeneRegulationandSignalTransduction,DepartmentofPharmacology,UniversityofCa...
analysis of the mRNA expression array of cells over-expressing miR-377 showed a fairly consistent correlation between miR-377 expression and regulation of known gene expression signatures of NFKB1A (IκBα) (Figure8B). This indirectly implies the involvement of miR-377 in the NF-κB pathway ...