In a single-center double-blind clinical trial, they assessed the efficacy of daily application of 2% nitroglycerin ointment over the course of 2 years in increasing bone mineral density (BMD). The study was not large enough to directly determine the drug's effects on fracture risk. The study...
Discard the used finger covering and wash hands after application of the ointment.DosageAdultsChronic Anal FissureRectal375 mg (1 inch) of 0.4% ointment (equivalent to 1.5 mg nitroglycerin) every 12 hours for ≤3 weeks.Improved outcomes (e.g., healing rates, reduction in pain) reported after...
RECTIV ointment was evaluated in a 3-week double-blind, randomized, multi-center, placebo-controlled study. Patients with a painful chronic anal fissure for at least 6 weeks and moderate or severe pain prior to treatment (≥ 50 mm on the 100mm visual analog scale, VAS) were randomized to ...
Amount of nitroglycerin reaching the circulation varies directly with the size of application area and amount of ointment applied. Generally, spread over an area approximately the size of the applicator (3.5 by 2.25 inches); however, may use a larger area (e.g., 6 by 6-inch area)....
Arterial blood pressure and heart rate increase during electroconvulsive therapy can be effectively attenuated by application of 2 inches of 2% nitroglycerin ointment 45 min before the electroconvulsive therapy (p < 0.001 and p < 0.01 resp.). This may be especially beneficial for patients who are ...
Synopsis: The recently introduced preparation of intravenous glyceryl trinitrate1 (nitroglycerin) provides a rapid steady therapeutic blood concentration o
25. Ointment comprising 0.5 to 3% GTN and 5 to 15% NAC. 26. Composition for IV administration comprising 5 to 400 mcg/ml GTN and 20 to 100 mg/ml NAC.Description: CROSS-REFERENCE TO RELATED APPLICATION This application claims the benefit of U.S. Provisional Patent Application No. 60/...
We have found the application of 2% nitroglycerine ointment to be a safe, inexpensive, comfortable and effective means of attenuating the pressor response to intubation of the trachea.doi:10.1111/j.1365-2044.1986.tb12954.xS KamraJ WigR P Sapru...
This drug (1 ml. of a 2% solution) was studied under strict laboratory conditions in a double-blind controlled trial on 33 patients (4 with neurogenic plus arterial, 10 with neurogenic and 19 with arterial impotence) and compared to placebo and nitroglycerin (2.5 gm. of a 10% ointment). ...
Nitrobid was associated with a rapid rise in nitroglycerin plasma concentrations maximal 1 h after application. Plasma concentrations of nitroglycerin absorbed from Nitrobid ointment fell below those absorbed from all three patch preparations after 8 h. Clinically, all four formulations were similar with...