德拉马尼(Delamanid,Dlm)在体内,外对处于复制,休眠期的结核分枝杆菌(Mycobacterium tuberculosis,MTB)均具有较强的杀灭作用.含Dlm的最佳背景方案(Optimised background regimen,OBR)治疗MDR-TB患者可增加2个月末的痰培养转阴率,并显著改善患者预后和降低病死率.本文主要对Dlm的药物特点,体外活性,动物实验,疗效和安全性...
德拉马尼(Delamanid,Dlm)在体内,外对处于复制,休眠期的结核分枝杆菌(Mycobacterium tuberculosis,MTB)均具有较强的杀灭作用.含Dlm的最佳背景方案(Optimised background regimen,OBR)治疗MDR-TB患者可增加2个月末的痰培养转阴率,并显著改善患者预后和降低病死率.本文主要对Dlm的药物特点,体外活性,动物实验,疗效和安全性...
对于高度耐药的结核病患者,如pre-XDR-TB、RR-TB,以及对氟喹诺酮类药物(FQ)的额外耐药,建议使用6~9个月的贝达喹啉(bedaquiline,Bdq)治疗方案或基于Bdq的长程治疗方案。由于安全问题,二线注射剂药物(SLI)在治疗耐药结核病中的作用受到...
Drug-resistant TB constitutes a significant threat because it underpins almost 25% of global TB mortality, is associated with high morbidity, is a threat to healthcare workers and is unsustainably costly to treat. The advent of highly resistant TB with emerging bacillary resistance to newer drugs...
Further research is needed to better understand appropriate conditions where linezolid-containing regimens will be able to perform best ( patient sub-groups, geographical settings, M. tuberculosis resistance patterns, concomitant drugs in the regimen, etc.). A final comment is that on top of ...
In 2022, only 43% of the total estimated multidrug-resistant Tuberculosis (MDR-TB) incident cases were diagnosed and enrolled on treatment regimen1 Only 47% of the total notified MDR-TB cases were tested for resistance to fluoroquinolones1 ...
Efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrug-resistant tuberculosis: a multicentre, randomised, double-blind, placebo-controlled, parallel group phase 3 trial. Lancet Respir Med. 2019;2600(18):1–12. https://doi.org/10.1016/S2213...
Astonishingly his sensitivity report turned out to be a case of XDR TB. Since there was no past history of Tuberculosis or inadvertent exposure to Antituberculosis drugs, he was diagnosed as a case of Primary XDRTB. He was put on retreatment regimen consisting of Kanamycin, Paraaminosalicylic ...
rooms), clinical management of TB, MDR-TB and HIV co-infection (inadequate bacteriological diagnosis, regimen selection and treatmentduration), laboratory support and diagnostic/treatment algorithms.Gaps between present international standards of care and the management of MDR/XDR-TBpatients were ...
The successful treatment regimen for tuberculosis was the most important paradigm in tuberculosis (TB) history. From the difficult journey through cure by regal touch, cod liver oil surgical collapse therapy and sanatorium management, we advanced to successful short course chemotherapy in the hope to ...