The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Coll
In the heart, soluble klotho significantly induces expression of NRF2, heat shock protein 70 (HSP70) and the antioxidant enzymes heme oxygenase (HO-1) and peroxiredoxin-1 (Prx-1) and enhances glutathione levels. R R Klotho inhibits angiotensin II-induced reactive oxygen species production. R Klot...
The α-KL protein is composed of two glycoside hydrolase (GH) motifs that are similar to enzymes in GH family 1. Recombinant human α-KL protein (human IgG1 Fc chimera protein) exhibits β-glucuronidase activity; however, two potentially catalytic glutamic acids in the GH motifs were mutated ...
phenotype was due to a cell-autonomous functional defect of Klotho in bone or systemic changes due to hyperphosphatemia and hypervitaminosis D. Another study usedPrx1Creto conditionally ablate Klotho in mesenchymal stem cells.Prx1Cre;KLfl/flmice revealed a skeletal phenotype comparable to controls;...
not available for EP1327443of corresponding document: US2003119910 The present invention provides a therapeutic or preventing agent for diseases caused by a decrease in the expression level of Klotho protein in animals or humans and a feed or food and drink for the treatment or prevention of such...
In the current study, our specific aim was to characterize the Klotho protein and expression levels in the hippocampus and prefrontal cortex of old rats treated with different diets (high-fat, high-protein, low-calorie, high-protein and low-calorie). Rat
Klotho is a vital aging suppressor protein that has emerged in recent years. The klotho encodes a transmembrane alpha klotho (α−klotho) protein that is abundant in the kidney and brain [1]. After shedding the amino-terminal extracellular domain [2], soluble α-klotho can be found in circ...
The α-Klotho is crucial for human health and longevity. However, the relationship between trace elements and α-Klotho levels needs further invest
We first generated the rhesus macaque form of the KL protein (96% homologous to human KL) and functionally validated its activity using assays in mice. This was the secreted, hormonal form (and not the transmembrane form) of the α-klotho protein. We tested a KL dose (10 μg kg−1...
Here, we report that β-klotho (KLB), a single-pass transmembrane protein known as a co-receptor for fibroblast growth factor 21 (FGF21), fine tunes GSIS via modulation of glycolysis in pancreatic β-cells independent of the actions of FGF21. β-cell-specific deletion of Klb but not Fgf...