而Klotho基因过表达可逆转肾小管上皮细胞中抗氧化酶的丢失,抑制过氧化氢诱导的丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)信号通路活化,减少含半胱氨酸的天冬氨酸蛋白水解酶-3(caspase-3)表达,提高Bcl-2/Bax比值,进而减轻细胞氧化损伤和细胞凋亡[...
Klotho proteinis a transmembrane enzyme first discovered in 1997. Reduced levels of Klotho are associated with chronic renal failure as well as with general aging of a variety of systems. In mice, decreased Klotho expression leads to a short lifespan, infertility, arteriosclerosis, skin atrophy, ...
Klotho enhances Mn-SOD expression (~2x), via activation of the cAMP signaling pathway and activation of the FoxO forkhead transcription factors that are negatively regulated by insulin/IGF-1 signaling. R R In the heart, soluble klotho significantly induces expression of NRF2, heat shock protein 70...
klotho protein 主页 产品 klotho protein 中文名klotho protein 英文名klotho protein 英文别名klotho protein
The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.而KLOTHO基因的多态性与人类的寿命、冠状动脉疾病、动脉粥样硬化...
【16】X.M. Su, W. Yang, Klotho protein lowered in elderly hypertension, Int J Clin Exp Med 7(8) 【17】(2014) 2347-50. H.L. Wang, Q. Xu, Z. Wang, Y.H. Zhang, L.Y. Si, X.J. Li, Q.H. Yang, H. Xiao, A potential regulator...
英文名称:Rat Klotho protein (Klotho) ELISA Kit 用途:用于科研实验使用 产地:深圳 品牌:瑞清 包装规格:96T 标记物:HRP 样本:血清.血浆.组织.相关液体等 检测方法:酶联免疫法 应用:仅供科研使用 检测限:详询 货号:RQ-FS6810A 是否进口:否 Elisa生物试验是一种敏感性高,特异性强,重复性好的实验诊断方法。由...
The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
样生长子结合蛋白5(IGFBP5)抗体 ELISAKitforInsulinLikeGrowthFactorBindingProtein5(IGFBP5) 规格:48T/96T 细胞周期素B(CCNB)抗体 ELISAKitforCyclinB(CCNB) 规格:48T/96T /葡萄糖协同转运蛋白2(SGLT2)抗体 ELISAKitforSodium/GlucoseCotransporter2(SGLT2) 规格:48T/96T ...
【16】X.M. Su, W. Yang, Klotho protein lowered in elderly hypertension, Int J Clin Exp Med 7(8) 【17】(2014) 2347-50. H.L. Wang, Q. Xu, Z. Wang, Y.H. Zhang, L.Y. Si, X.J. Li, Q.H. Yang, H. Xiao, A potential regulatory singlenucleotidepolymorphism in the promoter ...